Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years
Identifieur interne : 002752 ( Main/Exploration ); précédent : 002751; suivant : 002753Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years
Auteurs : Marwan I. Hariz [Royaume-Uni, Suède] ; Stig Rehncrona [Suède] ; Niall P. Quinn [Royaume-Uni] ; Johannes D. Speelman [Pays-Bas] ; Carin Wensing [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Complication, Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Deep brain stimulation, Female, Gait Disorders, Neurologic (etiology), Globus Pallidus (physiology), Globus Pallidus (radiation effects), Humans, Longitudinal Studies, Male, Mental Disorders (etiology), Middle Aged, Multicenter study, Nervous system diseases, Neurologic Examination, Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Subthalamic Nucleus (physiology), Subthalamic Nucleus (radiation effects), Subthalamic nucleus, adverse event, deep brain stimulation, globus pallidus, subthalamic nucleus..
- MESH :
- adverse effects : Deep Brain Stimulation.
- etiology : Gait Disorders, Neurologic, Mental Disorders.
- methods : Deep Brain Stimulation.
- physiology : Globus Pallidus, Subthalamic Nucleus.
- radiation effects : Globus Pallidus, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Case-Control Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination.
Abstract
Ongoing adverse events (AEs) at 4‐years postsurgery in 69 patients with advanced Parkinson′s disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow‐up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present “both with and without stimulation.” The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/F772162C9FD901268133E5448E5E96C496C7B350/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00391487
DOI: 10.1002/mds.21888
Affiliations:
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Le document en format XML
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At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow‐up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present “both with and without stimulation.” The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name></region><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name></country><country name="Suède"><noRegion><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name></noRegion><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Speelman, Johannes D" sort="Speelman, Johannes D" uniqKey="Speelman J" first="Johannes D." last="Speelman">Johannes D. Speelman</name></region><name sortKey="Wensing, Carin" sort="Wensing, Carin" uniqKey="Wensing C" first="Carin" last="Wensing">Carin Wensing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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